Fuzzing is an important technique to detect software bugs and vulnerabilities. It works by mutating a small set of seed inputs to generate a large number of new inputs. Fuzzers’ performance often substantially degrades when valid seed inputs are not available. Although existing techniques such as symbolic execution can generate seed inputs from scratch, they have various limitations hindering their applications in real-world complex software without source code. In this paper, we propose a novel fuzzing technique that features the capability of generating valid seed inputs. It piggy-backs on AFL to identify input validity checks and the input fields that have impact on such checks. It further classifies these checks according to their relations to the input. Such classes include arithmetic relation, object offset, data structure length and so on. A multi-goal search algorithm is developed to apply class specific mutations in order to satisfy inter-dependent checks all together. We evaluate our technique on 20 popular benchmark programs collected from other fuzzing projects and the Google fuzzer test suite, and compare it with existing fuzzers AFL and AFLFast, symbolic execution engines KLEE and S2E, and a hybrid tool Driller that combines fuzzing with symbolic execution. The results show that our technique is highly effective and efficient, out-performing the other tools.